FAS inhibitor C75(C-75
3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
CAS: 218137-86-1
Molecular Formula: C14H22O4
FAS inhibitor C75(C-75 - Names and Identifiers
FAS inhibitor C75(C-75 - Physico-chemical Properties
| Molecular Formula | C14H22O4 |
| Molar Mass | 254.32 |
| Density | 1.08±0.1 g/cm3(Predicted) |
| Boling Point | 432.1±45.0 °C(Predicted) |
| Solubility | DMSO: 18mg/mL |
| Appearance | solid |
| Color | off-white |
| pKa | 3.08±0.40(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | C75 inhibits PC3 cell growht with an IC 50 of 35 μM at 24 h. C75 (10-50 μM) also reduces the growth of LNCaP spheroids in a concentration-dependent manner with an IC 50 of 50 μM. (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and its administration produces anorexia, suggesting that central inhibition of CPT1 is essential for the anorectic effect of C75. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity. |
| In vivo study | C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA. |
FAS inhibitor C75(C-75 - Risk and Safety
| WGK Germany | 3 |
FAS inhibitor C75(C-75 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.932 ml | 19.66 ml | 39.321 ml |
| 5 mM | 0.786 ml | 3.932 ml | 7.864 ml |
| 10 mM | 0.393 ml | 1.966 ml | 3.932 ml |
| 5 mM | 0.079 ml | 0.393 ml | 0.786 ml |
Last Update：2024-01-02 23:10:35
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View History
FAS inhibitor C75(C-75
咪达唑仑杂质D
RuCl2[(S)-(DM-BINAP)][(S)-DAIPEN]
3-(三氟甲基)双环[1.1.1]戊烷-1-羧酸
2-脱氧-4-C-乙炔-2-氟腺苷酸
Direct Dark Brown NM
1-BUTYL-1-METHYLPYRROLIDINIUM BIS(TRIFLUOROMETHYLSULFONYL)IMIDE
Pasireotide Impurity 8
咪达唑仑杂质D
RuCl2[(S)-(DM-BINAP)][(S)-DAIPEN]
3-(三氟甲基)双环[1.1.1]戊烷-1-羧酸
2-脱氧-4-C-乙炔-2-氟腺苷酸
Direct Dark Brown NM
1-BUTYL-1-METHYLPYRROLIDINIUM BIS(TRIFLUOROMETHYLSULFONYL)IMIDE
Pasireotide Impurity 8